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Increased risk of mortality by twice due to undeniable link with fatty liver.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MDA-SLD) arises as a replacement for the earlier term 'fatty liver.' Despite the shift in nomenclature, this condition continues to pose significant threats, and recent findings reveal it can nearly double the likelihood of mortality...

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5 min read
Metabolic dysfunction-induced liver steatosis, previously known as fatty liver, still poses a...
Metabolic dysfunction-induced liver steatosis, previously known as fatty liver, still poses a significant threat to health, and recent studies reveal its capacity to nearly double the chances of death from various unconnected health issues.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), persists as a severe health concern. This condition arises when fat accumulates in the liver, often due to metabolic disorders such as type 2 diabetes or obesity.

Research has shown that MASLD can progress to more severe complications, such as metabolic dysfunction-associated steatohepatitis (MASH), which can lead to cirrhosis or significant liver fibrosis – the development of scar tissue in the liver. Left unmanaged, MASLD can result in deteriorating liver function or liver cancer, diabetes-related complications, and a higher risk of death from various causes, not limited to liver-related conditions.

In a recent study, researchers at the Karolinska Institutet in Sweden analyzed the risk of death in 13,099 MASLD patients compared to the general population. Their findings revealed an alarming trend: those with MASLD had a twice as high mortality rate overall, with a 27-fold increase in the risk of liver disease and 35-fold increase in liver cancer mortality. Interestingly, the most common causes of death for these patients were cardiovascular disease and non-liver cancer, respectively accounting for 54% and 47% higher mortality risks.

Study lead Axel Wester, an assistant professor at the Karolinska Institutet and physician at Karolinska University Hospital, highlights the need for early intervention and a holistic approach. "Many people are not aware that they have fatty liver disease because it rarely causes symptoms in the early stages," says Wester. "Our study shows that people diagnosed with MASLD have an increased risk of dying from many different diseases, not just liver disease."

The study further found that MASLD patients had an elevated risk of death from infectious diseases, gastrointestinal diseases, respiratory diseases, endocrine diseases, or external causes.

To minimize the risk of developing MASLD or experiencing its severe complications, medical experts recommend the following preventive measures:

  • Weight loss: Aim for at least a 10% weight loss if you are obese, or a 3 to 5% reduction even if you only need to shed a modest amount of weight.
  • Regular exercise: An exercise regimen enhances Kupffer cells' protective function for the liver in addition to aiding weight loss.
  • Blood sugar management: Minimizing your intake of added sugar, especially sugary drinks like soda and sweet treats, can help manage blood sugar levels.
  • Liver-friendly lifestyle: Quit smoking and limit alcohol consumption, if not abstaining completely, as these habits put additional stress on the liver.

The consumption of certain foods is also beneficial for liver health:

  • Coffee: Lowers abnormal liver enzymes.
  • Tofu: May reduce fat buildup in the liver.
  • Fish rich in omega-3s: Improves liver fat levels and reduces inflammation.
  • Avocados: May slow liver damage.
  • Low-fat milk and dairy products: Contains whey protein that may protect against liver damage.
  • Green tea: May help shedding liver fat.

In the early stages, MASLD typically causes no noticeable symptoms. When symptoms do appear, they may include vague complaints like fatigue, discomfort in the upper right abdomen, unexplained weight loss, muscle weakness, and edema. More pronounced symptoms don't emerge until the disease has progressed, such as confusion, behavioral changes, jaundice, easy bruising, itching, nausea, loss of appetite, and visible spider-like blood vessels on the skin. Early detection in high-risk individuals (such as those with obesity or diabetes) through blood tests and imaging is crucial for early diagnosis and successful management of MASLD.

  1. Science continues to explore the links between Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and chronic diseases like cancer and respiratory conditions.
  2. In the realm of workplace-wellness, MASLD is a medical condition that requires attention, as it can lead to diabetes-related complications.
  3. The healthcare industry is rallying to address the growing concern of MASLD and its progression to more severe conditions, such as MASH.
  4. Climate change and its impact on manufacturing processes might indirectly contribute to the rise of MASLD due to altered dietary habits and sedentary lifestyles.
  5. Mental health, skin care, and various therapies and treatments are essential for managing the symptoms and complications of MASLD.
  6. Proper nutrition, including a balanced diet rich in fruits, vegetables, and lean proteins, plays a significant role in maintaining digestive health and overall health-and-wellness.
  7. Fitness and exercise are recommended for weight management, cardiovascular health, and overall well-being, in addition to managing MASLD.
  8. Environmental-science research is exploring how pollutants and toxins in the air contribute to the development and progression of MASLD.
  9. Financially, the early treatment of MASLD can result in significant cost savings in the long run, reducing the burden on Medicare and private healthcare systems.
  10. The use of CBD, a natural compound found in cannabis, is being investigated for its potential benefits in managing symptoms associated with MASLD.
  11. In the realm of energy, promoting sustainable living and reducing exposure to harmful chemicals in the home can help lower the risk of MASLD.
  12. The retail sector plays a part in this fight, too, by offering healthier food options and promoting awareness about MASLD and its risk factors.
  13. Entrepreneurs are seizing opportunities to improve healthcare outcomes for MASLD patients through innovative approaches to fitness, nutrition, and tech solutions.
  14. The interior design industry is focusing on creating wellness-oriented spaces that prioritize exposure to natural light and indoor plants to support overall health and well-being.
  15. Transportation can also impact MASLD risk: regular physical activity, even through commuting, and choosing cleaner forms of transportation can contribute to a healthier lifestyle.
  16. Leadership in various industries should adopt a proactive approach to promoting workplace-wellness programs, emphasizing education and early intervention for MASLD and other medical conditions.
  17. Diversity and inclusion are essential in the healthcare sector, as individuals from different backgrounds and experiences can bring fresh perspectives and innovative solutions to the challenge of managing MASLD.
  18. Wearables and smart-home devices have the potential to monitor and manage various health factors, making it easier for individuals to track and manage their risk of MASLD.
  19. Cybersecurity is crucial in the healthcare industry, as the exchange of sensitive health information regarding MASLD requires robust protection against breaches and data leaks.
  20. Lifestyle choices, such as maintaining a healthy diet, exercising regularly, and avoiding smoking and excessive alcohol consumption, can reduce the risk of developing MASLD.
  21. Outdoor-living and gardening can contribute to sustainable living, reducing the exposure to air pollutants and providing access to fresh produce.
  22. The automotive industry is also evolving to incorporate greener technologies and options to promote healthier living within commuting habits.
  23. Small businesses can play a role in promoting workplace-wellness by offering benefits such as fitness programs, mental health resources, and wellness workshops.
  24. Investing in venture capital can support the growth and development of startups focused on addressing MASLD and other healthcare challenges.
  25. Wealth management goes beyond financial planning; it involves making informed decisions that prioritize long-term health and well-being.
  26. Home-and-garden improvement projects can focus on creating eco-friendly living spaces, further supporting sustainable living and reducing MASLD risk.
  27. Home-improvement retailers can contribute to the solution by offering eco-friendly products and promoting sustainable practices.
  28. The business sector should prioritize health and well-being in their operations, embracing career development and work-life balance to reduce stress and support overall health.
  29. Venture capitalists and private-equity firms can invest in health-focused startups and initiatives, creating a ripple effect of positive impact across industries, from fintech to real-estate, and the entire economy.

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